Clinical presentation and surgical management of Glomatosis Cerebri

ALQazaz, Mohamed Youssef; Mohamed Elsamahy, Mohamed

doi:10.21608/ijsrsd.2018.8536

Clinical presentation and surgical management of Glomatosis Cerebri

Document Type : Original Article

Authors

¹ Assistant professor of Neurosurgery, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

² Suez Canal University,Ismailia,Department of Neurology,Egypt

10.21608/ijsrsd.2018.8536

Abstract

Background: Glomatosis Cerebri (GC) is a diffuse brain neoplasm whose prognosis is unfavourable. Aim: to investigate the clinical presentation, radiological and pathological features, and outcomes after treatment of GC. Patients and Methods: We collected data from fifteen patients with GC treated at Suez Canal University, during a ten-year period. The diagnosis was based on magnetic resonance imaging (MRI) findings and tissue biopsy of all patients except one patient who received blind radiotherapy. Results: Seven patients were male (47%), and their median age at presentation was 43 years (range, 6 75 years). Statistical analysis demonstrated median survival as follows: blind radiotherapy, 1 month (n = 1); biopsy then radiotherapy, 19 months (8 32 months; n = 9); subtotal excision then radiotherapy, 5 months (1-7 months; n=5). Karnofsky Performance Scale scores of 70 and tumor grade were both significantly related to length of survival. Conclusion: Our findings suggest that biopsies are useful not only for diagnosis but also for prediction of the length of survival.

Keywords

Article Title [العربیة]

العرض السریری والإدارة الجراحیة لمرض الجلطات

Abstract [العربیة]

الملخص: تعتبر الجلیوما المخیه هو ورم دماغی منتشر غامض یکون تکهناته قاتمة. الهدف من الدراسة: کان الهدف من هذه الدراسة هو التحقیق فی الأعراض السریریة ، والسمات الإشعاعیة والمرضیة ، والنتائج بعد العلاج. المرضى والأسالیب: جمعنا بیانات بالورم الدبقی وعولجوا فی جامعة ً مصابا ً لخمسة عشر مریضا قناة السویس خلال فترة عشر سنوات. اعتمد التشخیص على نتائج التصویر بالرنین المغناطیسی وتحلیل الأنسجة لجمیع المرضى باستثناء واحد حصل على العلاج الإشعاعی. النتائج: کان سبعة مرضى من الذکور . سنة) 47 - 6 سنة (المدى من 74 ) ، وکان متوسط العمر عند التشخیص ٪ 74(
1النتائج: أظهر التحلیل الإحصائی فترة البقاء على المدى المتوسط على النحو التالی: العلاج الإشعاعیة ، ) ؛ استئصال غیر 1 شهرا ؛ ع = 43 - 8 شهرا ( 11) ؛ عینه من الورم ثم العلاج الإشعاعی ، 1شهر (ع = ). کان کلا من مقیاس کارنوفسکی أکبر من أو 7 أشهر ؛ ع = 4-1 أشهر ( 7 کلی ثم العلاج الإشعاعی ، وکذلک مستوی الورم لهما ارتباطا کبیرا بطول البقاء على قید الحیاة. الخلاصة: توحی النتائج ٪٠٧یساوی . ا للتنبؤ بمدة البقاء علی قید الحیاة ً

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